The Role of Vitamins B3 and C in the Treatment of Histadelia
نویسنده
چکیده
rumination, mental fogginess, disperceptions, and hyperactivity (overarousal) characterize the psychiatric manifestations of histadelia, a type of schizophrenia. The nonpsychiatric clinical features of histadelia include: increased salivation, elevated metabolic rate, allergic symptoms, frequent headaches, diminished pain threshold, heightened sexual responsiveness (a greater ability to achieve orgasm), and strong cravings for sugar. Increased basophils (greater than 50 cells/mm) and elevated blood histamine levels (greater than 70 ng/ ml) confirm the diagnosis of histadelia. The goal of orthomolecular treatment for this disorder is to restore blood histamine levels to normal. This can be achieved through dietary modifications (low protein and high fruit/vegetable diet), a combination of various nutrients (calcium, methionine, zinc, and manganese), and sometimes the drug phenytoin (Dilantin). A low protein diet reduces the amount of ingested L-histidine, which is a precursor to histamine. Calcium helps mobilize bodily stores of histamine, and also might increase histamine catabolism. Methionine lowers blood histamine by reacting with histamine to form N-methylhistamine, an inert methylated ring structure. Zinc and manganese replenish possible deficiencies, and phenytoin negates the compulsive behaviors and depression. It has been proposed that the histadelic patient does not respond “to the classical meganutrient (B3, vitamin C) therapy.” This lack of response is confusing considering that thousands of schizophrenic patients have benefited from taking megadoses of vitamins B3 and C. If 20% of all schizophrenics are thought to have histadelia, it is possible that favorable therapeutic responses to vitamins B3 and C have occurred among many histadelic patients. The therapeutic potential of vitamins B3 and C in the treatment of histadelia is clear given the biochemical functions of these vitamins.
منابع مشابه
P 50: A Review on the Role and Efficacy of Vitamins in Depression
Depression, as a mental disorder, affects more than 300 million people of all ages every year. It is said to be associated with neuroinflammation. Depression has affected women more than men. Over the world, people are disabled due to depression rather than any other condition. Neuroinflammation is the brain’s reaction to injury. Apparently there is a link between neuroinflammation and de...
متن کاملP 71: A Review on the Role and Efficacy of Vitamins in Depression
Depression, as a mental disorder, affects more than 300 million people of all ages every year. It is said to be associated with neuroinflammation. Depression has affected women more than men. Over the world, people are disabled due to depression rather than any other condition. Neuroinflammation is the brain’s reaction to injury. Apparently there is a link between neuroinflammation and de...
متن کاملProtective Effect of Vitamins E and C on Endosulfan-Induced Reproductive Toxicityin Male Rats
Background: The role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. This study was performed to evaluate the possible protective effect of vitamins E and C, against endosulfan-induced reproductive toxicity in rats. Methods: Fifty adult male Sprague–Dawley rats were randomly divided into five groups (n=10 each). The groups included a control receivin...
متن کاملAntioxidant effect of different vitamins on methemoglobin production: An in vitro study
Nitrite intoxication occurs frequently in ruminants and equines. The most common treatment of this disorder is administration of 1% methylene blue, although the use of some antioxidant agents e.g. vitamins and complementary treatment may also be useful. The aim of this study was to evaluate the in vitro antioxidative effects of some vitamins on methemoglobinemia induced by sodium nitrite. For t...
متن کاملP145: Vitamins Level Change in Spinal Cord Injury
Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. Studies showed that individuals with SCI has a clear tendency to vitamins level change. The aim of this study was to review the vitamins level in spinal cord injury. Vitamins C level decrease in the injured spinal cord patient. Vitamins C hav...
متن کامل